eTOXsys delivers access to highly relevant proprietary data, donated by pharmaceutical organisations through the eTOX database, and public data, through the RepDose database.
The eTOX database contains over 1,900 compounds and 8,000 associated repeat dose studies*. This data has been derived from proprietary data donated by the 13 pharmaceutical eTOX partners. Figure 1 shows the spread of treatment related histopathology findings in the database.
Figure 1: The top 10 treatment related histopathology findings in the database (as of November 2016)
The chemical space covered by the eTOX database is highly relevant for drug discovery and development. Figure 2 provides a visualisation of the clear correlation of the chemical space of the eTOX database when compared to that of marketed drugs.
DrugBank Approved v5.0.3
Figure 2: A representation of chemical coverage in the eTOX database when compared to marketed drugs. (Visualisation produced in StarDrop, Optibrium Ltd, Cambridge, UK)
*Correct at time of writing